Foot and Mouth Disease Bivalent (Type O and A) Vaccine, Inactivated Instructions

[Veterinary Drug Name] Foot and Mouth Disease Bivalent (Type O and A) vaccine, Inactivated

(strain O/MYA98/BY/2010 ＋strain Re-A/WH/09)

[Main Ingredients]

The vaccine contains two components (inactivated foot-and-mouth disease virus O/MYA98/BY/2010 strains and A/Re-A/WH/09 strains). The total antigen (146S) included type O and type A should not be less than 1.0μg/ml. The titer of O type virus is not less than 107.5 LD50 in 0.2ml (or not less than 10 7. 5 TCID50 in 1ml) and the titer of A type virus is not less than 107.0 LD50 in 0.2ml (or not less than 10 7. 5 TCID50 in 1ml).

[Characteristics] Milky white emulsion with slight viscosity.. 

[Function and Purpose] It is used to prevent type O and type A foot-and-mouth disease in cattle and

sheep. The immunization period is 6 months.

For the prevention of Swine foot-and-mouth disease type O and A. The immune period is 6 months.

[Usage and Dosage] Intramuscular injection. For bovine, each animal shall be injected with 1.0ml. For sheep and goat, each animal shall be injected with 0.5ml..

[Adverse Reactions]

 (1) Normal reaction: No obvious changes in spirit and appetite after injection. No reaction in injection area, no influence in lactation, only transient increase in body temperature it will

recovery within 1 day, and no other visible changes in clinical signs.

(2) Minor adverse reaction: Slight swelling at the injection site and persistent increase in body temperature in individual animals 0.5 ~ 1 °C, reduce or stop eating for 1 ~ 2 meals, cows can have a transient decrease in lactation, with the extension of time, the symptoms gradually reduce and disappear.

(3) Serious adverse reactions: Due to breed and individual differences, individual cattle may have acute allergic reactions caused by allergens after vaccination (such as restlessness, rapid breathing, muscle tremor, visual mucosal congestion, rumen bulging, nasal bleeding, etc., and even death due to untimely rescue. A few pregnant cows may have abortion).

[Precautions]

(1) The vaccine should be refrigerated during transported at 2~8 °C, not frozen, and the transportation time should as short as possible. Avoid direct sunlight during transportation and use.

(2) Inspection the vaccine before use. If the following conditions are found in the vaccine (such as impurity in the vaccine, bottle cracked or not tightly sealed, the emulsion broken, vaccine deteriorated), it should not be used.The vaccine should be brought back to room temperature and shaken well before use. The vaccine should be used within 24 hours after opening.

(3) This vaccine only inoculates healthy animal. Sick animals, emaciated animal, late pregnancy female animals and young animals should be used with caution.

(4) Strictly abide by the operating procedures. Injection equipment should be sterilized and injection sites should be disinfection before injection. The needle should be replaced after injection. Operator who contacted with sick animals can’t vaccinated until changing their clothes, hats, shoes and carrying out necessary disinfection.

(5) The vaccine can be used in non-epidemic areas, risk areas, and epidemic areas. The vaccination sequence should be started at non-epidemic areas to epidemic areas. Before large-scale usage, the vaccine should be tested first, and then gradually expand the scope of usage after confirm the safety.

(6) In non-epidemic areas, the animal can only carry out transportation after 21 days.

(7) During the emergency epidemic control, except emergency vaccination, other comprehensive

prevention and control measures should be carry out at the same time.

(8) When individual animal have severe allergic reactions, veterinarian should be rescued with

epinephrine or other drugs, and appropriate adjuvant treatment measures should be carry out at

the same time.

(9)The vaccine bottle,injection equipment and unspent vaccine should be sterilized.

[Strength]

(1) 20ml/ bottle

(2) 50ml/ bottle

(3) 100ml/ bottle

(4) 250ml/ bottle

[Package]

(1) 20ml/ bottle ×100 bottles/box

(2) 50ml/ bottle ×40 bottles/box

(3) 50ml/ bottle ×100 bottles/box

(4) 100ml/ bottle ×50 bottles/box

(5) 250ml/ bottle ×50 bottles/box

[Storage and Shelf-life] The shelf-life is 18 months when kept at 2-8℃.

[Approval Number] Veterinary Drug Approval No. .280187538

[Manufacturer] Lanzhou Branch of Shanghai Shen Lian Biomedical Corporation

[Address] NO.2398 Kun Longshan Avenue, Lanzhou New Area, Lanzhou, Gansu Province, China